Methylation Detection in the islands of 16INK4A CpG P, RASSF 1 and promoters of gene methyl-guanine methyl-transferase (PT.2) in adenocarcinoma of the pancreas

D. Paikos, p. Voyatzi Stravoravdi, s., i. Boukovinas, p. Kiziridou Papakotoulas, r., g. Sibilidis and i. Stergiou

Pancreatic cancer consists of an accumulation of genetic and epigenetic alterations. Recently, aberrant methylation of CPG islands of cancer-related genes has emerged as an important epigenetic mechanism of their transcriptional dysregulation during development of the cancer.

Therefore, new diagnostic methods for the early detection, based on a better understanding of the molecular biology of cancer of the pancreas, are required.

We examin methylation status of p16INK4A, 1 RASSF and genes MGMT considered be inactivated by the promoter methylation in various cancers.

Volume: 3 article number: 131 DOI: 10.3332/ecancer. 2009 131 received: 22/12/2008 published: 15/01/2009

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