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Potential contribution of aspirin to cancer control programs
G. Morgan
Abstract
Chemoprevention describes the potential of chemicals to intervene and stop the multistage carcinogenesis. Aspirin (Acetilsalicilato) is showing potential chemopreventivi cancer and medicine has potential for public health, since low-doses also reduce the risk of cardiovascular events up to 30%. While acknowledging that aspirin has undesirable effects, perhaps medicine can compliment other cancer control programs, such as screening and lifestyle measures.In addition, maybe the potential cancer chemopreventivi aspirin could be mediated in part by salicylate which is present in fruits and vegetables.Salicylate might be considered therefore a nutraceutical. Furthermore, there are a number of issues that arise including the potential for the public health sector to further support the agenda prior to self-care, which might include aspirin. Maybe now is appropriate for the potential of public health of aspirin to be convened a Conference.
Keywords:
aspirin, cancer control, salicylate, nutraceutical, public health
Volume: 2 article number: 100 DOI: 10.3332/100 ecancer. 2008. received: 12/10/2008 published: 12/11/2008
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Surgical treatment is damage control ‘ of a great Liposarcoma retroperitoneal bordering a horseshoe kidney
B. Andreoni, a. Chiappa, u. peace, e. Bertani, f. Verweij, f. bears, g. Petralia, Tullii M, m. Venturino, g. Pelosi
Damage control is a surgical strategy for patients seriously compromised trauma based on speed control for fatal accidents which aims to resuscitate quickly patients in intensive care unit (ICU). we have a report about the use of such therapeutic strategy in patients affected by a concomitant retroperitoneal sarcoma of a horseshoe kidney, a relatively rare anatomical malformation.
Volume: 2 article number: 77 DOI: 10.3332/ecancer. 2008.77 received: 04/03/2008 published: 07/07/2008
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PstI/RsaI DraI polymorphisms and CYP2E1 and head and neck cancer risk: a meta analysis based on case control studies 21
Cytochrome P450 CYP2E1 encodes a member of the superfamily of enzymes that play a central role in stimulating and detoxifying many carcinogens and endogenous compounds, thought to participate in the development of cancer. PstI/RsaI and DraI polymorphism are two of the most widely studied gene polymorphisms for their association with risk of cancers of the head and neck, but the results are conflicting. Methods: we do meta analysis using the 21 entitled in case control studies 4.951 patients and 6.071 elements for summarizing data on association between CYP2E1 PstI/RsaI and DraI polymorphism and risk of head and neck cancer, especially by interacting with smoking or alcohol. Results: compared to wild-type genotype or was 1.96 (95% CI: 1.33-2.90) for PstI/RsaI and 1.56 (95% CI: 1.07-2) polymorphism for DraI, respectively. When stratified according to ethnic origin, or an Asian for both polymorphisms (or = 2.04, 95% CI: 1.32-3.15 PstI/RsaI; OR = 2.04, 95% CI: 1.27-3.29 for DraI), suggesting that the risk is more pronounced in Asia. Conclusion: our meta analysis suggests that the homozygote genotypes PstI/RsaI or polymorphism DraI can be associated with increased risk of head and neck cancer, especially in Asia.
cancer3 