Response to neo-adjuvant chemotherapy for colorectal liver metastasis of cancer: a key to improving the survival?

R. Bertani Chiappa, e., r. Biffi, u. peace

Liver Resection in colorectal cancer metastatic disease offers the best chance in cases selected for the long-term survival. Intravenous pyelogram (NACT) Chemotherapy was supported in some cases initially deemed irresectable, with few reports the effectiveness of this strategy and the influence of chemoresponsiveness on the outcome of radical liver resection. Methodology: Between December 1995 and 27 patients with colorectal liver metastases, May 2005 (7 20 females, males, mean age: 58 8 years; range: 40-75) were treated with chemotherapy neoadjuvant chemotherapy.You performed a survival analysis of 7 years. Chemotherapy included mainly 5-fluorouracil, leucovorin and Oxaliplatin and irinotecan to a median of 8 courses.

Sixteen patients (59%) had synchronous and 11 metastasis metachronous (41%). during the regression of cancer chemotherapy pre that occurred in 10 cases (37%); stable disease (SD) in a further 10 patients (37%) and the progressive disease (PD) developed in 7 cases (26%). Year 5 General survival for NACT responders was 64% and only 15% for non-responders (p = 0.044).

The response to chemotherapy is likely to be a significant prognostic factor affecting the survival after liver resection for care.

Volume: 1 article number: 58 DOI: 10.3332/ecancer. 2008 58 received: 20/08/2007 published: 16/10/2007

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Metachronous bladder metastasis from renal cell carcinoma: a case report and literature review

S. Melegari, g. Albo, Rocco b., f. Verweij, m. extremly high and o. de Cobelli

Introduction: adrenal gland, Parotid gland, pharynx, eye and bladder are rare metastasis localizations of renal cell carcinoma (RCC). We report a case of metachronous RCC bladder metastasis in a patient with a past history of transitional cell (TCC) Carcinoma of the bladder. Method: cause description and review of the literature were performed.Results: During the last follow up cistoscopy a singular, lesion 5 mm was noticed and endoscopically resected. Was to be a recurrence of TCC but nature JRC was confirmed and compared to primitive kidney cancer.
Conclusion: The patient had a probability of secondarism three years after the nefrectomy of 62.9%.3 and 5 years survival after singular metastasectomy are 60% and 38%; diagnosis metachronous had a better prognosis than synchronous. during RCC follow-up any breach should be considered a secondarism possible.

Volume: 4 article number: 175 DOI: 10.3332/ecancer. 2010.175 received: 21/12/2009 published: 18/03/2010

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